Clinical Practice Guidelines (CPG)

Policies and updates

Clinical practice guidelines help address conditions frequently seen in patients at your practice. All CPGs included have been reviewed and approved by CalOptima’s Clinical Quality Improvement Committee. All CPGs are connected to links that are simple to access and include algorithms for quick reference. A detailed document accompanies each algorithm. CalOptima is confident you will find these CPGs valuable to your daily practice. Please contact CalOptima’s Quality Improvement department if you would like to see links to other CPGs available on this site. We are happy to include additional CPGs once approved by the Clinical Quality Improvement Committee.


Asthma Download PDF Icon Guidelines for the diagnosis and management of asthma by the National Heart, Lung, and Blood Institute.

Alcohol misuse

Screening, diagnosis and referral for substance use disorders U.S. Prevention Services Task Force (USPSTF) 2013 recommendation statement on screening and behavioral counseling interventions in primary care to reduce alcohol misuse.

Attention deficit/hyperactivity disorder (ADHD)

ADHD: CPG for the diagnosis, evaluation and treatment of ADHD in children and adolescents CPGs from the American Academy of Pediatrics (AAP) in 2011 on the diagnosis and treatment of ADHD in children and adolescents.


Autism  Download PDF Icon American Academy of Child & Adolescent Psychiatry practice parameter in 2014 for the assessment and treatment of children and adolescents with autism spectrum disorder (ASD).

Cervical cancer screening

Cervical cancer screening Download PDF Icon Screening guidelines for the prevention and early detection of cervical cancer published by the National Institutes of Health Public Access Author Manuscript provided by the American Cancer Society, American Society for Coloscopy and Cervical Pathology, and the American Society for Clinical Pathology.

Chronic obstructive pulmonary disease (COPD)

COPD Download PDF Icon Guidelines for the management of COPD exacerbations in 2017 by the European Respiratory Society/American Thoracic Society.

Major depression in adults

Major depression in adults American College of Physicians clinical recommendations in 2016 on the comparative effectiveness of treatment with second-generation antidepressants versus nonpharmacologic treatments for major depressive disorder in adults.

Diabetes mellitus

Diabetes mellitus Download PDF Icon American Diabetes Association: Standards of Medical Care in Diabetes — 2017.

Obesity in adults

Obesity Download PDF Icon The National Institutes of Health (NIH) practical guide in 2000 for identification, evaluation and treatment of overweight and obesity in adults.

Childhood obesity

Childhood obesity American Academy of Pediatrics (AAP) expert committee recommendations in 2007 regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity.

Prenatal care

Update on prenatal care  Download PDF Icon American Academy of Family Practitioners recommendations for providers of prenatal care (this is an updated version of the article that appeared in print).

Late-term and postterm pregnancy Download PDF Icon American Academy of Family Physicians 2014 clinical content with common questions and answers about late-term and postterm pregnancy.

Streptococcal pharyngitis

Streptococcal pharyngitis Download PDF Icon Diagnosis and treatment published in 2009 by the American Academy of Family Physicians.

Tobacco use and dependence

Treating tobacco use and dependence  Download PDF Icon U.S. Department of Health and Human services 2008 update on treating tobacco use and dependence.

Transgender affirming care

Transgender affirming care Download PDF Icon University of California, San Francisco’s Center of Excellence for Transgender Health Guidelines in 2016 to address disparities by equipping primary care providers and health systems with the tools and knowledge to meet the health care needs of their transgender and gender nonconforming patients.

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